PodcastRx with Chris Bender - April 2025

Topic

News

Clinical pharmacist Henry So joins Chris for some back and forth around blood pressure goals.

Listen here or where you enjoy podcasts!

When it comes to managing hypertension and reducing adverse cardiovascular events, what is the ideal blood pressure figure clinicians should target? OPTICS pharmacist Henry So joins Chris for some back and forth around this question. They look at the evolution (and proliferation) of blood pressure guidelines, examine controversies around certain studies, share some of their own personal experiences with hypertension, and ultimately whether they think a lower number is necessarily better.

Before that, Chris shares some quick drug approval and guideline updates, and afterwards, we end things with a look at back at how the death of a US President 80 years ago sounded the alarm on the dangers of untreated hypertension.

Links to Material Discussed in the Episode-

Into the Clinic:

FDA Approves First New Class of Oral Antibiotics for Uncomplicated UTIs in Nearly 30 Years

Antimicrobial Activity of Gepotidacin Tested against Escherichia coli and Staphylococcus saprophyticus Isolates Causing Urinary Tract Infections in Medical Centers Worldwide (2019 to 2020)

2025 ACC/AHA/ACEP/NAEMSP/SCAI Guideline for the Management of Patients With Acute Coronary Syndromes: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines

Glucagon-like peptide-1 receptor agonists and risk of suicidality among patients with type 2 diabetes: active comparator, new user cohort study

High Price of GLP-1 Agents Tip Cost-Benefit Scale Unfavorably

FDA issues limited acne product recalls, AAD releases statement on benzoyl peroxide

Main Discussion:

Evidence for the Universal Blood Pressure Goal of <130/80 mm Hg Is Strong

A Randomized Trial of Intensive versus Standard Blood-Pressure Control

The SPRINT Trial: Cons

SPRINT: More Controversy And Confusion About ‘Landmark’ Trial

2020 International Society of Hypertension Global Hypertension Practice Guidelines

Global and European landscape of major hypertension guidelines

Blood Pressure Targets in Adults With Hypertension:  A Clinical Practice Guideline From the AAFP

Association of Blood Pressure Classification in Young Adults Using the 2017 American College of Cardiology/American Heart Association Blood Pressure Guideline With Cardiovascular Events Later in Life

Hyperkalemia and Acute Kidney Injury with Spironolactone Use Among Patients with Heart Failure

Long-Term Effects of Spironolactone on Kidney Function and Hyperkalemia-Associated Hospitalization in Patients with Chronic Kidney Disease

Trivia Capsule:

Harold on History | Historical Perspectives on Hypertension